Determination of Sulfate and Sulfamate in Topiramate Using a Reagent-Free Ion Chromatography System
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چکیده
Introduction Epilepsy is a common neurological disorder that can cause anywhere from a brief cessation of responsiveness to severe muscle spasms with a loss of consciousness.1 This condition is usually controlled with antiepileptic drugs (AEDs). However, approximately 20% of patients with epilepsy are resistant to therapy with first-generation AEDs.2 Topiramate (Topamax®) is a second-generation AED approved by the FDA for the treatment of partial seizures (with or without secondarily generalized seizures), seizures associated with Lennox Gastaut Syndrome, and primary generalized tonic-clonic seizures in patients that are inadequately controlled by conventional first-generation AEDs.3 Topiramate has also been shown to be effective in the prophylactic treatment of migraine headaches.
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تاریخ انتشار 2016